Corneal Changes & Migraine

Study Goals

In this study we hope to define the relationship between nerve changes in the cornea and migraine symptoms. Migraine in children is not uncommon, and in a number of cases is accompanied by other conditions such as Dry Eye Syndrome. Children and adolescents with migraine will be examined in order to evaluate the onset of corneal nerve changes that may contribute to existing migraine symptoms. Determining the relationship between corneal changes and migraine in a pediatric population could offer a new method of migraine treatment, one that could be co-managed by optometrists, ophthalmologists, pediatricians, and neurologists.

Study Involvement

Participants will also undergo an examination of their eyes using a corneal microscope and MRI scanning. Participants will also fill out self-assessment questionnaires to measure migraine symptoms and determine dry eye severity and pain intensity if present.

Eligibility to Participate

Seeking 9-18 year old individuals with a clinical diagnosis of episodic migraine (<15 per month). Must have normal vision and hearing and ability to lie still for a 30 minute MRI scan.

Healthy subjects ages 9-18 will also be eligible to participate.

Study Visit Overview

All study visits will be conducted at the Boston Children’s Hospital at Waltham (9 Hope Avenue). The study can be completed in one or two visits and includes the following:

1. Completion of questionnaires (15-20 minutes)

2. Eye Exam (30 minutes)

3. MRI prep and scan (45 minutes)


Participants will receive $100 for completing the study and a CD with a picture of their brain.


Discretionary funds from the Center for Pain and the Brain and the Department of Anesthesiology.


To learn more about this study, please contact Dr. Eric Moulton at [email protected]