Ankle Sprain

Study Goals

We are interested in tracking how the brains and nerves of people with ankle injuries develop over time. This information may lead to a better understanding of the neurological consequences of neuropathic pain, or chronic pain where nerve fibers have been damaged from an injury.  This study may lead to more knowledge on neuropathic pain and better treatment for patients.

Our Approach

We are using a variety of neuroimaging MRI techniques, including functional MRI and Diffusion Tensor Imaging, to examine the nerve and brain over time.

Eligibility to Participate

Seeking 10 – 24 year olds with a recent (<1 month) lower extremity injury, such as an ankle sprain.  Healthy 10 – 24 year old individuals are also eligible to participate in the control group of the study.

Study Visit Overview

Study Visit takes place at Boston Children’s Hospital in Waltham (9 Hope Avenue). The study will involve between 1 to 4 visits and each visit will take up to 3 hours.  Each study visit includes the following:

1. Neurological evaluation (15 minutes)

2. Pre-scan psychological questionnaires (30 minutes)

3. Sensory Testing (10 minutes)

4. Leg and Brain MRI scan (90 minutes)


Participants will receive a $100 gift card for the first study session they participate in, as well as a CD with pictures of their brain to take home.


This study is supported by the NIH.


To learn more about this study, please email [email protected]